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MedColorimeter

Diagonestics for the developing World

Med-Colorimeter is essentially a simple paper cartage integrated with a smartphone-type device for rapid testing of pathological samples. Considering the benefits of spot diagnosis, these sorts of diagnostic tools are likely to be very helpful for primary healthcare centres and thus will be minimizing the efforts of the clinicians and will simultaneously reduce the unnecessary crowds.

The following unique features are stated below :
(1) Ultra-low cost fabrication of the pathological platform with the aid of a simple office printer or a Table top CNC machine
(2) Detecting multiple diseases simultaneously in a single paper cartridge, deploying only one drop of blood/ urine saliva.
(3) Improved functionality from limited resource settings.

about us

About the Device : Our Med-Colorimeter is essentially premised on paper based microfluidic technology. Paper-and-pencil based microfluidic technology, innovated by one of the founding Directors of the Company, combines the benefits of fluid flow through small passages (capillary action) and electrical actuation in the same device has shown a great potential for point-of-care diagnostics recently. The potential of this technology has been recognized for wide spectrum applications ranging from simple to complex assays. Such microfluidic systems use small sample volumes enabling rapid reaction times, self-propulsion of fluids, automated fluidic handling and cost-effective use of materials and reagents. Furthermore, it is also found suitable for efficient batch processing, multiplexing, and high throughput screening applications. Considering the current rural healthcare landscape of the developing world, this paper strip is integrated with a portable electronic platform which is capable of sensing and detection, integrated with a smart/low power sources and operational from environmentally challenged locations.

Present Status of the Device : Although a few portable pathological diagnostic devices have already been commercialized (e.g. glucometer, malaria strips, pregnancy kits etc.) and seem to have good response in terms of on-field testing, detection of very trace amount of bio-analytes is still found as a challenge and therefore needs significant improvement in terms sensitivity. Technologists have demonstrated the usage of sophisticated instrumentation for improving the quantification limit, but it increases the involved expenses of the diagnosis.


Further, automation for result analysis, multiplexing (i.e., simultaneous detection of target diseases), integrating with a powering systems and environmental control, as well as integrating with a data-driven primary healthcare decision making system is still a challenge. With unique validation employing clinical samples, we provide a generic solution to this end, through our generic Med-Colorimeter that may be suitably customized to have disease specific functionalities, given a colorimetric protocol on hand.

Relevant Patents filed by our founder Director:
1. A Portable Paper-Based Microfludic Platform for Rapid Diagnosis of Antimicrobial Susceptibility Assays
2. A 'Paper-And-Pencil'-Based Diagnostic Kit for Ready and Simultaneous Detection of One Or Multiple Analytes







People

about us

Prof. Suman Chakraborty


Founder Director

Chair Professor, IIT Kharagpur
Department of Mechanical Engineering, IIT Kharagpur
Dean, SRIC, IIT Kharagpur
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Acknowledgement - Faculty Member, Researchers and Students





Research

Diagonestics for the developing World

Short Research Presentation of the Product

Diagonestics for the developing World

Diagnostics appears to be the most essential component that needs to be integrated with any healthcare practice, concerning issues ranging from early detection of diseases to administering prompt and effective treatment. The standard diagnostic facilities that are currently being deployed are not only inadequate in addressing pertinent challenges specific to the developing and the under-developed world, but are also often turn out to be restricted in addressing the needs of the developed community. Moreover, the available healthcare facilities are grossly inaccessible to the rural and economically backward population, predominant in the developing world. Furthermore, the standard laboratory-based diagnostic protocols are labour intensive, time consuming, require elaborate infrastructure and significant volumes of costly chemicals, and expert on-field pathologists. Hence, in resource-limited settings, such diagnostic processes are restricted to the concerned population from accessing quality healthcare. In such scenarios, extreme environmental conditions and lack of trained staff pose serious challenge to provide comprehensive primary healthcare that include timely diagnosis, intervention, and management of diseases.

It has now been realized that innovative, low cost but effective point-of-care diagnostic technologies may be a solution in this direction with significant humanitarian, social and economic benefits. Delivery of primary care locally has important implications. For example, it is estimated that one third of the maternal deaths in the developing world occur due to anaemia. This can be corrected through iron-folic acid supplementation through a primary care centre. Consider a situation when a patient located in a resource-limited place is suffering from an ailment that necessitates rapid diagnostics. In the present scenario, the patient needs to be transported to a primary healthcare centre (may be located far off). Thereafter, collected physiological samples are transported to sophisticated laboratories for elaborate analysis. Often this is not well-affordable. Further, by the time the test results are available, the patient's condition may become far from being critical due to elaborate time-consuming investigations.

On contrary, consider a small hand-held device, which requires small amount of physiological sample (blood/ urine/ saliva/ sweat/ tear) for preliminary diagnosis. The device may be integrated with a smartphone (or similar handheld device with the relevant functionalities) for rapid and easy diagnosis (both qualitative and quantitative) of any suspected disease.

Despite advances in the related technological domain, products based on such technologies have rarely been translated into industrial practice. On the other hand, in pathological diagnostics, there is a dire need of affordable and robust technologies which can provide rapid and on-spot diagnostics, with minimal consumption of physiological samples and chemicals.

Point-of-Care Diagnostics

Point-of-care diagnosis has seen the recent advances worldwide, with initial application in healthcare industries where there are lesser constraints in terms of skills and environment as compared to developing countries. To improve the dismal state of current healthcare settings in a major part of the global population, there is an urgent need to adopt alternative diagnostic tools and/or protocols. Emphasis is now shifting towards extreme point-of-care solutions to address the striking demand for effective healthcare where it is needed most. As per the recent criteria set by world healthcare organization (WHO), the present point-of-care diagnosis technology should be Affordable, Sensitive, Specific, User friendly, Rapid, Robust, Equipment free and Deliverable to end users.


about us

Med-Colorimeter

Our Med-Colorimeter is essentially a simple paper cartage integrated with a smartphone-type device for rapid testing of pathological samples, with the following unique features: (1) Ultra-low cost fabrication of the pathological platform with the aid of a simple office printer or a Table top CNC machine (2) Detecting multiple diseases simultaneously in a single paper cartridge, deploying only one drop of blood/ urine saliva. (3) Improved functionality from limited resource settings. Considering the benefits of spot diagnosis, these sorts of diagnostic tools are likely to be very helpful for primary healthcare centers and thus will be minimizing the efforts of the clinicians and will simultaneously reduce the unnecessary crowds..


About the Device

Our Med-Colorimeter is essentially premised on paper based microfluidic technology. Paper-and-pencil based microfluidic technology, innovated by one of the founding Directors of the Company, combines the benefits of fluid flow through small passages (capillary action) and electrical actuation in the same device has shown a great potential for point-of-care diagnostics recently. The potential of this technology has been recognized for wide spectrum applications ranging from simple to complex assays. Such microfluidic systems use small sample volumes enabling rapid reaction times, self-propulsion of fluids, automated fluidic handling and cost-effective use of materials and reagents. Furthermore, it is also found suitable for efficient batch processing, multiplexing, and high throughput screening applications. Considering the current rural healthcare landscape of the developing world, this paper strip is integrated with a portable electronic platform which is capable of sensing and detection, integrated with a smart/low power sources and operational from environmentally challenged locations.



Although a few portable pathological diagnostic devices have already been commercialized (e.g. glucometer, malaria strips, pregnancy kits etc.) and seem to have good response in terms of on-field testing, detection of very trace amount of bio-analytes is still found as a challenge and therefore needs significant improvement in terms sensitivity. Technologists have demonstrated the usage of sophisticated instrumentation for improving the quantification limit, but it increases the involved expenses of the diagnosis. Further, automation for result analysis, multiplexing (i.e., simultaneous detection of target diseases), integrating with a powering systems and environmental control, as well as integrating with a data-driven primary healthcare decision making system is still a challenge. With unique validation employing clinical samples, we provide a generic solution to this end, through our generic Med-Colorimeter that may be suitably customized to have disease specific functionalities, given a colorimetric protocol on hand.


Unique Features

The unique features of the instrument are as follows
(1) Ultra-low cost fabrication of the pathological platform with the aid of a simple office printer or a Table top CNC machine
(2) Detecting multiple diseases simultaneously in a single paper cartridge, deploying only one drop of blood/ urine saliva.
(3) Improved functionality from limited resource settings.


Relevant Patents

1. A Portable Paper-Based Microfluidic Platform for Rapid Diagnosis of Antimicrobial Susceptibility Assays
2. A 'Paper-And-Pencil'-Based Diagnostic Kit for Ready and Simultaneous Detection of One Or Multiple Analytics







Contact Me

Directly Contact Us through our phone number or just drop a message. Incase you want to send us some notes or send suggestion also please be free to contact us.

Prof. Suman Chakraborty

Department of Mechanical Engineering, IIT Kharagpur
Dean, SRIC, IIT Kharagpur
Kharagpur -721302, West Bengal, India

( Phone : 91-9932242598, Email : suman@mech.iitkgp.ernet.in)